Curated Information
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PubMed Id: 16260496 
Yamaguchi T, et al. (2005) Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis. J Cell Biol 171, 431-6 16260496
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S56-p - Vimentin (mouse)
Orthologous residues
Vimentin (human): S56‑p, Vimentin (mouse): S56‑p, Vimentin (rat): S56‑p, Vimentin (hamster): S55‑p, Vimentin (cow): S56‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [PLK1 (human)], COS (fibroblast) [Vimentin (mouse)], T24 (bladder cell) [PLK1 (human)], T24 (bladder cell) [Vimentin (mouse)], U251 (glial) [PLK1 (human)], U251 (glial) [Vimentin (mouse)]
 Cellular systems studied:  cell lines
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (mouse)
Downstream Regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLK1 (human) Induces activity, induced far-Western

S72-p - Vimentin (mouse)
Orthologous residues
Vimentin (human): S72‑p, Vimentin (mouse): S72‑p, Vimentin (rat): S72‑p, Vimentin (hamster): S71‑p, Vimentin (cow): S72‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [PLK1 (human)], COS (fibroblast) [Vimentin (mouse)], T24 (bladder cell) [PLK1 (human)], T24 (bladder cell) [Vimentin (mouse)], U251 (glial) [PLK1 (human)], U251 (glial) [Vimentin (mouse)]
 Cellular systems studied:  cell lines

S73-p - Vimentin (mouse)
Orthologous residues
Vimentin (human): S73‑p, Vimentin (mouse): S73‑p, Vimentin (rat): S73‑p, Vimentin (hamster): S72‑p, Vimentin (cow): G73‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [PLK1 (human)], COS (fibroblast) [Vimentin (mouse)], T24 (bladder cell) [PLK1 (human)], T24 (bladder cell) [Vimentin (mouse)], U251 (glial) [PLK1 (human)], U251 (glial) [Vimentin (mouse)]
 Cellular systems studied:  cell lines

S83-p - Vimentin (mouse)
Orthologous residues
Vimentin (human): S83‑p, Vimentin (mouse): S83‑p, Vimentin (rat): S83‑p, Vimentin (hamster): S82‑p, Vimentin (cow): S83‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast) [PLK1 (human)], COS (fibroblast) [Vimentin (mouse)], T24 (bladder cell) [PLK1 (human)], T24 (bladder cell) [Vimentin (mouse)], U251 (glial) [PLK1 (human)], U251 (glial) [Vimentin (mouse)]
 Cellular systems studied:  cell lines
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) transfection of inactive enzyme, transfection of constitutively active enzyme


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