Curated Information

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Curated Information Page

PubMed Id: 10826493

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Sánchez C, Pérez M, Avila J (2000) GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. Eur J Cell Biol 79, 252-60 10826493

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T259-p - MAP2 iso3 (rat)

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Orthologous residues

MAP2 (human): T1616‑p, MAP2 iso2 (human): T260‑p, MAP2 iso3 (human): T1612‑p, MAP2 iso4 (human): T317‑p, MAP2 (mouse): T1620‑p, MAP2 iso2 (mouse): ‑, MAP2 iso6 (mouse): T259‑p, MAP2 (rat): T1622‑p, MAP2 iso2 (rat): T1622‑p, MAP2 iso3 (rat): T259‑p

Characterization

Methods used to characterize site in vivo: microscopy-colocalization with upstream kinase, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: COS (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	GSK3B (human)	phospho-antibody, transfection of inactive enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme

Downstream Regulation

Effect of modification (process): cytoskeletal reorganization

Comments: caused decrease in microtubule bundles

T262-p - MAP2 iso3 (rat)

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