Curated Information
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Curated Information Page
PubMed Id: 10826493 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sánchez C, Pérez M, Avila J (2000) GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundling. Eur J Cell Biol 79, 252-60 10826493
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T259-p - MAP2 iso3 (rat)
Orthologous residues
MAP2 (human): T1616‑p, MAP2 iso2 (human): T260‑p, MAP2 iso3 (human): T1612‑p, MAP2 iso4 (human): T317‑p, MAP2 (mouse): T1620‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): T259‑p, MAP2 (rat): T1622‑p, MAP2 iso2 (rat): T1622‑p, MAP2 iso3 (rat): T259‑p
Characterization
 Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) phospho-antibody, transfection of inactive enzyme, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  caused decrease in microtubule bundles

T262-p - MAP2 iso3 (rat)
Orthologous residues
MAP2 (human): T1619‑p, MAP2 iso2 (human): T263‑p, MAP2 iso3 (human): T1615‑p, MAP2 iso4 (human): T320‑p, MAP2 (mouse): T1623‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): T262‑p, MAP2 (rat): T1625‑p, MAP2 iso2 (rat): T1625‑p, MAP2 iso3 (rat): T262‑p
Characterization
 Methods used to characterize site in vivo microscopy-colocalization with upstream kinase, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) phospho-antibody, transfection of inactive enzyme, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization
 Comments:  caused decrease in microtubule bundles


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