Curated Information
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PubMed Id: 9920892 
Bodeau-Péan S, et al. (1999) A human tyrosine hydroxylase isoform associated with progressive supranuclear palsy shows altered enzymatic activity. J Biol Chem 274, 3469-75 9920892
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S31-p - TH iso3 (human)
Orthologous residues
TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro
Associated Diseases
Diseases: Alterations: Comments:
PSP decreased TH isoform lacking S31 and S40 is overexpressed in PSP patients

S40-p - TH iso3 (human)
Orthologous residues
TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro
Associated Diseases
Diseases: Alterations: Comments:
PSP decreased TH isoform lacking S31 and S40 is overexpressed in PSP patients


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