Curated Information
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Curated Information Page
PubMed Id: 9819392 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Roof RW, et al. (1998) Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Mol Cell Biol 18, 7052-63 9819392
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1087-p - GRF-1 (mouse)
Orthologous residues
GRF‑1 (human): Y1087‑p, GRF‑1 (mouse): Y1087‑p, GRF‑1 (rat): Y1087‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mass spectrometry, mutation of modification site, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  C3H10T1/2 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines

Y1105-p - GRF-1 (mouse)
Orthologous residues
GRF‑1 (human): Y1105‑p, GRF‑1 (mouse): Y1105‑p, GRF‑1 (rat): Y1105‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mass spectrometry, mutation of modification site, phosphopeptide mapping, western blotting
 Relevant cell lines - cell types - tissues:  C3H10T1/2 (fibroblast), COS (fibroblast)
 Cellular systems studied:  cell lines
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (chicken) transfection of wild-type enzyme, activation of upstream enzyme
KINASE EGFR (human) transfection of wild-type enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (human) Induces molecular association, regulation co-immunoprecipitation, in vitro


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