Curated Information
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Curated Information Page
PubMed Id: 9312046 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Bourette RP, Myles GM, Choi JL, Rohrschneider LR (1997) Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling. EMBO J 16, 5880-93 9312046
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y697-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y699‑p, CSFR (mouse): Y697‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  FDCP-1 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y706-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y708‑p, CSFR (mouse): Y706‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  FDCP-1 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y721-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y723‑p, CSFR (mouse): Y721‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  FDCP-1 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MCSF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (mouse) SH2 Induces molecular association, regulation, enzymatic activity, induced cell differentiation, altered pull-down assay, in vitro
PLCG1 (mouse) SH2 Induces molecular association, regulation, enzymatic activity, induced cell differentiation, altered pull-down assay, in vitro
PLCG1 (mouse) SH2 Induces molecular association, regulation yeast two-hybrid

Y807-p - CSFR (mouse) ▲
Orthologous residues
CSFR (human): Y809‑p, CSFR (mouse): Y807‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  FDCP-1 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PLCG1 (mouse) SH2 Induces enzymatic activity, induced cell differentiation, altered pull-down assay, in vitro


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