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Orthologous residues
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Shc1 (human): Y427‑p, Shc1 iso2 (human): Y317‑p, Shc1 iso3 (human): Y272‑p, Shc1 iso6 (human): Y428‑p, Shc1 iso7 (human): Y318‑p, Shc1 (mouse): Y423‑p, Shc1 iso2 (mouse): Y313‑p, Shc1 iso3 (mouse): Y268‑p, Shc1 (rat): Y423‑p
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Characterization
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Methods used to characterize site in vivo:
immunoprecipitation, western blotting
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|
Relevant cell lines - cell types - tissues:
B6SUtA1 (hematopoietic progenitor)
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Cellular systems studied:
cell lines
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Species studied:
mouse
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Upstream Regulation
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|
Treatments, proteins and their effect on site modification:
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|
Treatments
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Referenced Treatments
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Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
IL-3
|
|
|
|
increase
|
|
|
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Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Effect of modification (process):
apoptosis, induced
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
SHIP (mouse)
|
SH2
|
Induces
|
|
apoptosis, altered
|
co-immunoprecipitation, plasmon resonance, in vitro
|
|
|
Comments:
in vitro and in vivo
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