Curated Information
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Curated Information Page
PubMed Id: 9083021 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Liu L, et al. (1997) The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. J Biol Chem 272, 8983-8 9083021
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Y423-p - Shc1 (mouse)
Orthologous residues
Shc1 (human): Y427‑p, Shc1 iso2 (human): Y317‑p, Shc1 iso3 (human): Y272‑p, Shc1 iso6 (human): Y428‑p, Shc1 iso7 (human): Y318‑p, Shc1 (mouse): Y423‑p, Shc1 iso2 (mouse): Y313‑p, Shc1 iso3 (mouse): Y268‑p, Shc1 (rat): Y423‑p, Shc1 iso2 (rat): Y313‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, western blotting
 Relevant cell lines - cell types - tissues:  B6SUtA1 (hematopoietic progenitor)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  apoptosis, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHIP (mouse) SH2 Induces apoptosis, altered co-immunoprecipitation, in vitro, plasmon resonance
 Comments:  in vitro and in vivo


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