Curated Information
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Curated Information Page
PubMed Id: 9020117 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Emlet DR, Moscatello DK, Ludlow LB, Wong AJ (1997) Subsets of epidermal growth factor receptors during activation and endocytosis. J Biol Chem 272, 4079-86 9020117
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Y1016-p - EGFR (human)
Orthologous residues
EGFR (human): Y1016‑p, EGFR iso5 (human): Y1016‑p, EGFR (mouse): Y1018‑p, EGFR (rat): Y1017‑p, EGFR (pig): Y1016‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  A431 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation, receptor internalization, altered
 Effect of modification (process):  endocytosis, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) SH2 Induces molecular association, regulation co-immunoprecipitation
RASA1 (human) SH2 Induces molecular association, regulation co-immunoprecipitation
SOS1 (human) Induces molecular association, regulation co-immunoprecipitation
Grb2 (human) SH2 Disrupts molecular association, regulation co-immunoprecipitation


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