Curated Information
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Curated Information Page
PubMed Id: 11029056 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Ozer RS, Halpain S (2000) Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton. Mol Biol Cell 11, 3573-87 11029056
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1679-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1679‑p, MAP2 iso2 (human): S323‑p, MAP2 iso3 (human): S1675‑p, MAP2 iso4 (human): S380‑p, MAP2 (mouse): S1680‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S319‑p, MAP2 (rat): S1682‑p, MAP2 iso2 (rat): S1682‑p, MAP2 iso3 (rat): S319‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), microscopy-colocalization with upstream kinase, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) microscopy-colocalization, mutation in upstream enzyme recognition motif, activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBA1A (human) Induces cytoskeletal reorganization microscopy-colocalization
ACTB (human) Induces cytoskeletal reorganization microscopy-colocalization

S1710-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1710‑p, MAP2 iso2 (human): S354‑p, MAP2 iso3 (human): S1706‑p, MAP2 iso4 (human): S442‑p, MAP2 (mouse): S1711‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S381‑p, MAP2 (rat): S1744‑p, MAP2 iso2 (rat): S1713‑p, MAP2 iso3 (rat): S350‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), microscopy-colocalization with upstream kinase, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) microscopy-colocalization, mutation in upstream enzyme recognition motif, activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ACTB (human) Induces cytoskeletal reorganization microscopy-colocalization
TUBA1A (human) Induces cytoskeletal reorganization microscopy-colocalization

S1782-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1782‑p, MAP2 iso2 (human): S426‑p, MAP2 iso3 (human): S1778‑p, MAP2 iso4 (human): S514‑p, MAP2 (mouse): S1783‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S453‑p, MAP2 (rat): S1816‑p, MAP2 iso2 (rat): S1785‑p, MAP2 iso3 (rat): S422‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), microscopy-colocalization with upstream kinase, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) microscopy-colocalization, mutation in upstream enzyme recognition motif, activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBA1A (human) Induces cytoskeletal reorganization microscopy-colocalization
ACTB (human) Induces cytoskeletal reorganization microscopy-colocalization


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