Curated Information
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Curated Information Page
PubMed Id: 10464310 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Larsson H, Klint P, Landgren E, Claesson-Welsh L (1999) Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem 274, 25726-34 10464310
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T202-p - ERK1 (human) ▲
Orthologous residues
ERK1 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF Crk (human) inhibit treatment-induced increase Crk SH2 mutant

Y204-p - ERK1 (human) ▲
Orthologous residues
ERK1 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF Crk (human) inhibit treatment-induced increase Crk SH2 mutant

T185-p - ERK2 (human) ▲
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF Crk (human) inhibit treatment-induced increase Crk SH2 mutant

Y187-p - ERK2 (human) ▲
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF Crk (human) inhibit treatment-induced increase Crk SH2 mutant

Y463-p - FGFR1 (human) ▲
Orthologous residues
FGFR1 (human): Y463‑p, FGFR1 iso21 (human): Y494‑p, FGFR1 (mouse): Y463‑p, FGFR1 (rat): Y370‑p, FGFR1 iso2 (rat): Y463‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Crk (human) SH2 Induces phosphorylation, molecular association, regulation co-immunoprecipitation, in vitro

Y766-p - FGFR1 (human) ▲
Orthologous residues
FGFR1 (human): Y766‑p, FGFR1 iso21 (human): Y797‑p, FGFR1 (mouse): Y766‑p, FGFR1 (rat): Y673‑p, FGFR1 iso2 (rat): Y766‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig


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