Curated Information

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Curated Information Page

PubMed Id: 19386264

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

ten Klooster JP, et al. (2009) Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell 16, 551-62 19386264

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T567-p - ezrin (human)

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Orthologous residues

ezrin (human): T567‑p, ezrin (mouse): T567‑p, ezrin (rat): T567‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Disease tissue studied: colorectal cancer, colorectal carcinoma

Relevant cell lines - cell types - tissues: Ls174T (intestinal), W4

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ROCK1 (human)
KINASE	MST4 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	MST4 (human)	siRNA inhibition of enzyme, genetic knockout/knockin of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
doxycycline				increase
		LKB1 (human)		increase

Downstream Regulation

Effect of modification (function): activation

Effect of modification (process): cytoskeletal reorganization

T178-p - MST4 (human)

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