Curated Information
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Curated Information Page
PubMed Id: 19332537 
Abe Y, et al. (2009) p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem 284, 14939-48 19332537
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S260-p - CCT-beta (human)
Orthologous residues
CCT‑beta (human): S260‑p, CCT‑beta (mouse): S260‑p, CCT‑beta (rat): S260‑p, CCT‑beta (cow): S260‑p
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293 (epithelial), 293T (epithelial), HMEC (endothelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE p90RSK (human)
KINASE Akt1 (human)
KINASE p70S6K (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) pharmacological inhibitor of upstream enzyme, phospho-motif antibody, transfection of wild-type enzyme
KINASE p90RSK (human) pharmacological inhibitor of upstream enzyme, phospho-motif antibody, transfection of wild-type enzyme
KINASE p70S6K (human) pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme, phospho-motif antibody, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
EGF increase
insulin increase
U0126 insulin no effect upon treatment-induced increase
LY294002 insulin inhibit treatment-induced increase
rapamycin insulin inhibit treatment-induced increase
siRNA insulin inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered
 Comments:  regulates cell proliferation

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