Curated Information
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Curated Information Page
PubMed Id: 8327466 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ullrich SJ, et al. (1993) Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53. Proc Natl Acad Sci U S A 90, 5954-8 8327466
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S9-p - p53 (human) ▲
Orthologous residues
p53 (human): S9‑p, p53 (mouse): S9‑p, p53 iso2 (mouse): S12‑p, p53 (rat): S9‑p, p53 (rabbit): S9‑p, p53 (monkey): S9‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
 Relevant cell lines - cell types - tissues:  Calu 6 (pulmonary), T98G (glial) [p53 (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  T98G derivatives expressing p53 wild-type (GM47.23), Ala15 mutant (GM15.41), or Ala37 mutant (GM37.0)

S15-p - p53 (human) ▲
Orthologous residues
p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
 Relevant cell lines - cell types - tissues:  Calu 6 (pulmonary), T98G (glial) [p53 (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  T98G derivatives expressing p53 wild-type (GM47.23), Ala15 mutant (GM15.41), or Ala37 mutant (GM37.0)

S20-p - p53 (human) ▲
Orthologous residues
p53 (human): S20‑p, p53 (mouse): S20‑p, p53 iso2 (mouse): S23‑p, p53 (rat): S20‑p, p53 (rabbit): S20‑p, p53 (monkey): S20‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
 Relevant cell lines - cell types - tissues:  Calu 6 (pulmonary), T98G (glial) [p53 (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  T98G derivatives expressing p53 wild-type (GM47.23), Ala15 mutant (GM15.41), or Ala37 mutant (GM37.0)

S315-p - p53 (human) ▲
Orthologous residues
p53 (human): S315‑p, p53 (mouse): S309‑p, p53 iso2 (mouse): S312‑p, p53 (rat): S313‑p, p53 (rabbit): S313‑p, p53 (monkey): S315‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
 Relevant cell lines - cell types - tissues:  Calu 6 (pulmonary), T98G (glial) [p53 (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  T98G derivatives expressing p53 wild-type (GM47.23), Ala15 mutant (GM15.41), or Ala37 mutant (GM37.0)

S392-p - p53 (human) ▲
Orthologous residues
p53 (human): S392‑p, p53 (mouse): S386‑p, p53 iso2 (mouse): ‑, p53 (rat): S390‑p, p53 (rabbit): S390‑p, p53 (monkey): S392‑p
Characterization
 Methods used to characterize site in vivo:  2D analysis, phosphopeptide mapping, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma, lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma
 Relevant cell lines - cell types - tissues:  Calu 6 (pulmonary), T98G (glial) [p53 (human), transfection]
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  T98G derivatives expressing p53 wild-type (GM47.23), Ala15 mutant (GM15.41), or Ala37 mutant (GM37.0)


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