Curated Information
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Curated Information Page
PubMed Id: 8947042 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Gotoh N, Tojo A, Shibuya M (1996) A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3. EMBO J 15, 6197-204 8947042
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y349-p - Shc1 (human)
Orthologous residues
Shc1 (human): Y349‑p, Shc1 iso2 (human): Y239‑p, Shc1 iso3 (human): Y194‑p, Shc1 iso6 (human): Y349‑p, Shc1 iso7 (human): Y239‑p, Shc1 (mouse): Y349‑p, Shc1 iso2 (mouse): Y239‑p, Shc1 iso3 (mouse): Y194‑p, Shc1 (rat): Y349‑p, Shc1 iso2 (rat): Y239‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited

Y350-p - Shc1 (human)
Orthologous residues
Shc1 (human): Y350‑p, Shc1 iso2 (human): Y240‑p, Shc1 iso3 (human): Y195‑p, Shc1 iso6 (human): Y350‑p, Shc1 iso7 (human): Y240‑p, Shc1 (mouse): Y350‑p, Shc1 iso2 (mouse): Y240‑p, Shc1 iso3 (mouse): Y195‑p, Shc1 (rat): Y350‑p, Shc1 iso2 (rat): Y240‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited

Y427-p - Shc1 (human)
Orthologous residues
Shc1 (human): Y427‑p, Shc1 iso2 (human): Y317‑p, Shc1 iso3 (human): Y272‑p, Shc1 iso6 (human): Y428‑p, Shc1 iso7 (human): Y318‑p, Shc1 (mouse): Y423‑p, Shc1 iso2 (mouse): Y313‑p, Shc1 iso3 (mouse): Y268‑p, Shc1 (rat): Y423‑p, Shc1 iso2 (rat): Y313‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, immunoprecipitation, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor')
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered


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