Curated Information
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Curated Information Page
PubMed Id: 9632795 
Takahashi-Tezuka M, et al. (1998) Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase. Mol Cell Biol 18, 4109-17 9632795
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y759-p - gp130 (human)
Orthologous residues
gp130 (human): Y759‑p, gp130 iso4 (human): , gp130 iso7 (human): , gp130 (mouse): Y757‑p, gp130 (rat): Y758‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces molecular association, regulation co-immunoprecipitation
 Comments:  necessary for ERK2 activation


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