Curated Information

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Curated Information Page

PubMed Id: 7700361

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Rosen MK, et al. (1995) Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. Nature 374, 477-9 7700361

Y221-p - Crk (mouse)

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Orthologous residues

Crk (human): Y221‑p, Crk iso2 (human): ‑, Crk (mouse): Y221‑p, Crk (rat): Y221‑p, Crk (chicken): Y222‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Abl (human)

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
Crk (mouse)	SH2	Induces			NMR spectroscopy

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