Curated Information
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Curated Information Page
PubMed Id: 16275913 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rinehart J, et al. (2005) WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A 102, 16777-82 16275913
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T96-p - NKCC2 (rat)
Orthologous residues
NKCC2 (human): T100‑p, NKCC2 (mouse): T96‑p, NKCC2 iso3 (mouse): , NKCC2 (rat): T96‑p, NKCC2 (rabbit): T99‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Cellular systems studied:  cell lines
 Species studied:  frog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE WNK3 (human) transfection of inactive enzyme, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hypertonic buffer increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization

T101-p - NKCC2 (rat)
Orthologous residues
NKCC2 (human): T105‑p, NKCC2 (mouse): T101‑p, NKCC2 iso3 (mouse): T96‑p, NKCC2 (rat): T101‑p, NKCC2 (rabbit): T104‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Cellular systems studied:  cell lines
 Species studied:  frog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE WNK3 (human) transfection of inactive enzyme, transfection of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hypertonic buffer increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization


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