Curated Information
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Curated Information Page
PubMed Id: 19135240 
Sumara G, et al. (2009) Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136, 235-48 19135240
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S203-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S205‑p, PKD1 (mouse): S203‑p, PKD1 (rat): S203‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)

S206-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S208‑p, PKD1 (mouse): S206‑p, PKD1 (rat): S206‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)

S255-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S249‑p, PKD1 (mouse): S255‑p, PKD1 (rat): S255‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)

S403-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S397‑p, PKD1 (mouse): S403‑p, PKD1 (rat): S403‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  MIN6 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Comments:  in vitro

S407-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S401‑p, PKD1 (mouse): S407‑p, PKD1 (rat): S407‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  MIN6 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Comments:  in vitro

S748-p - PKD1 (mouse)
Orthologous residues
PKD1 (human): S742‑p, PKD1 (mouse): S748‑p, PKD1 (rat): S748‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38D (human)


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