Curated Information
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Curated Information Page
PubMed Id: 16356855 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sommer K, et al. (2005) Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity 23, 561-74 16356855
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S564-p - CARD11 (mouse) ▲
Orthologous residues
CARD11 (human): S559‑p, CARD11 (mouse): S564‑p, CARD11 (chicken): S575‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCB (human)
KINASE PKCT (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester, ionomycin increase
Downstream Regulation
 Effect of modification (function):  activation, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Bcl-10 (human) Induces in vitro

S649-p - CARD11 (mouse) ▲
Orthologous residues
CARD11 (human): S644‑p, CARD11 (mouse): S649‑p, CARD11 (chicken): S660‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCB (human)
KINASE PKCT (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester, ionomycin increase

S657-p - CARD11 (mouse) ▲
Orthologous residues
CARD11 (human): S652‑p, CARD11 (mouse): S657‑p, CARD11 (chicken): S668‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCT (human)
KINASE PKCB (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester, ionomycin increase
Downstream Regulation
 Effect of modification (function):  activation, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Bcl-10 (human) Induces in vitro


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