Curated Information
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Curated Information Page
PubMed Id: 16360038 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Rubin SM, Gall AL, Zheng N, Pavletich NP (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123, 1093-106 16360038
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S788-p - Rb (human)
Orthologous residues
Rb (human): S788‑p, Rb (mouse): S781‑p, Rb (rat): S780‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
E2F1 (human) Disrupts in vitro
TFDP1 (human) Disrupts in vitro
 Comments:  In vitro = Isothermal calorimetry. E2F1-TFDP1 heterodimer.

S795-p - Rb (human)
Orthologous residues
Rb (human): S795‑p, Rb (mouse): S788‑p, Rb (rat): S787‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TFDP1 (human) Disrupts in vitro
E2F1 (human) Disrupts in vitro
 Comments:  In vitro = Isothermal calorimetry. E2F1-TFDP1 heterodimer.

S807-p - Rb (human)
Orthologous residues
Rb (human): S807‑p, Rb (mouse): S800‑p, Rb (rat): S799‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)

S811-p - Rb (human)
Orthologous residues
Rb (human): S811‑p, Rb (mouse): S804‑p, Rb (rat): S803‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)

T821-p - Rb (human)
Orthologous residues
Rb (human): T821‑p, Rb (mouse): T814‑p, Rb (rat): T813‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TFDP1 (human) Disrupts pull-down assay, in vitro
Rb (human) Induces pull-down assay
E2F1 (human) Disrupts pull-down assay, in vitro
 Comments:  Induces binding of C-terminus to pocket of Rb which can compete away the E2F1-TFDP1 which also binds the pocket. In vitro = Isothermal calorimetry.

T826-p - Rb (human)
Orthologous residues
Rb (human): T826‑p, Rb (mouse): T819‑p, Rb (rat): T818‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
E2F1 (human) Disrupts pull-down assay, in vitro
TFDP1 (human) Disrupts pull-down assay, in vitro
Rb (human) Induces pull-down assay
 Comments:  Induces binding of C-terminus to pocket of Rb which can compete away the E2F1-TFDP1 which also binds the pocket. In vitro = Isothermal calorimetry.


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