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Orthologous residues
|
|
LRP6 (human): T1479‑p, LRP6 (mouse): T1479‑p, LRP6 (rat): ‑
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|
Characterization
|
|
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phospho-antibody
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|
Relevant cell lines - cell types - tissues:
293T (epithelial) [CK1-G1 (human)], 293T (epithelial) [LRP6 (human)], fibroblast-embryo [CK1-G1 (human)], fibroblast-embryo [LRP6 (human)]
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|
Cellular systems studied:
cell lines
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|
Species studied:
human, mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
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Upstream Regulation
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|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
CK1-G1 (human)
|
transfection of dominant-negative enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
Wnt
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
activation
|
