Curated Information
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Curated Information Page
PubMed Id: 16341016 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Davidson G, et al. (2005) Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867-72 16341016
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T1479-p - LRP6 (human)
Orthologous residues
LRP6 (human): T1479‑p, LRP6 (mouse): T1479‑p, LRP6 (rat):
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [CK1G1 (human)], 293T (epithelial) [LRP6 (human)], fibroblast-embryo [CK1G1 (human)], fibroblast-embryo [LRP6 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1G1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK1G1 (human) transfection of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Wnt increase
Downstream Regulation
 Effect of modification (function):  activity, induced


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