Curated Information
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Curated Information Page
PubMed Id: 15312165 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hamada M, et al. (2004) Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. J Neurochem 90, 1094-103 15312165
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T34-p - DARPP-32 (mouse) ▲
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, neostriatum'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nicotine decrease low concentrations of nicotine
raclopride nicotine inhibit treatment-induced decrease low concentrations of nicotine
SCH 23390 nicotine augment treatment-induced decrease low concentrations of nicotine
mecamylamine nicotine inhibit treatment-induced decrease low concentrations of nicotine
DHbetaE nicotine inhibit treatment-induced decrease low concentrations of nicotine
alpha-BTX nicotine no effect upon treatment-induced decrease low concentrations of nicotine
MK801 nicotine no effect upon treatment-induced decrease low concentrations of nicotine
CNQX nicotine no effect upon treatment-induced decrease low concentrations of nicotine
cyclosporin A increase
nicotine increase high concentrations of nicotine
raclopride nicotine augment treatment-induced increase high concentrations of nicotine
SCH 23390 nicotine inhibit treatment-induced increase high concentrations of nicotine
MK801 nicotine inhibit treatment-induced increase high concentrations of nicotine
CNQX nicotine inhibit treatment-induced increase high concentrations of nicotine


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