Curated Information
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Curated Information Page
PubMed Id: 19264966 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Smith H, et al. (2009) Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. Proc Natl Acad Sci U S A 106, 4584-90 19264966
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

K355-ub - IRAK1 (human)
Orthologous residues
IRAK1 (human): K355‑ub, IRAK1 iso4 (human): K355‑ub, IRAK1 (mouse): K355‑ub, IRAK1 (rat): K355‑ub
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE UBE2D4 (human)
UBIQUITIN LIGASE UBE2D1 (human)
UBIQUITIN LIGASE UBE2D2 (human)
UBIQUITIN LIGASE PELI1 (human)

K397-ub - IRAK1 (human)
Orthologous residues
IRAK1 (human): K397‑ub, IRAK1 iso4 (human): K397‑ub, IRAK1 (mouse): K397‑ub, IRAK1 (rat): K397‑ub
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE PELI1 (human)
UBIQUITIN LIGASE UBE2D2 (human)
UBIQUITIN LIGASE UBE2D1 (human)
UBIQUITIN LIGASE UBE2D4 (human)

S70-p - PELI1 (human)
Orthologous residues
PELI1 (human): S70‑p, PELI1 (mouse): S70‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK1 (human)
KINASE IRAK4 (human)

S76-p - PELI1 (human)
Orthologous residues
PELI1 (human): S76‑p, PELI1 (mouse): S76‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

S78-p - PELI1 (human)
Orthologous residues
PELI1 (human): S78‑p, PELI1 (mouse): S78‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK1 (human)
KINASE IRAK4 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

T80-p - PELI1 (human)
Orthologous residues
PELI1 (human): T80‑p, PELI1 (mouse): T80‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

S82-p - PELI1 (human)
Orthologous residues
PELI1 (human): S82‑p, PELI1 (mouse): S82‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

T86-p - PELI1 (human)
Orthologous residues
PELI1 (human): T86‑p, PELI1 (mouse): T86‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

T127-p - PELI1 (human)
Orthologous residues
PELI1 (human): T127‑p, PELI1 (mouse): T127‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)

K169-ub - PELI1 (human)
Orthologous residues
PELI1 (human): K169‑ub, PELI1 (mouse): K169‑ub
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE UBE2D4 (human)
UBIQUITIN LIGASE UBE2D2 (human)
UBIQUITIN LIGASE PELI1 (human)
UBIQUITIN LIGASE UBE2D1 (human)

K202-ub - PELI1 (human)
Orthologous residues
PELI1 (human): K202‑ub, PELI1 (mouse): K202‑ub
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE UBE2D2 (human)
UBIQUITIN LIGASE UBE2D1 (human)
UBIQUITIN LIGASE UBE2D4 (human)
UBIQUITIN LIGASE PELI1 (human)

K266-ub - PELI1 (human)
Orthologous residues
PELI1 (human): K266‑ub, PELI1 (mouse): K266‑ub
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE UBE2D2 (human)
UBIQUITIN LIGASE UBE2D1 (human)
UBIQUITIN LIGASE PELI1 (human)
UBIQUITIN LIGASE UBE2D4 (human)

T288-p - PELI1 (human)
Orthologous residues
PELI1 (human): T288‑p, PELI1 (mouse): T288‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IL-1R
 Cellular systems studied:  cell lines
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

S293-p - PELI1 (human)
Orthologous residues
PELI1 (human): S293‑p, PELI1 (mouse): S293‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE IRAK4 (human)
KINASE IRAK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, ubiquitination

T290-p - PELI2 (human)
Orthologous residues
PELI2 (human): T290‑p, PELI2 iso2 (human): , PELI2 (mouse): T289‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  IL-1R
 Cellular systems studied:  cell lines
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IRAK1 (human) transfection of inactive enzyme, transfection of wild-type enzyme


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