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Orthologous residues
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|
p53 (human): S315‑p, p53 (mouse): S309‑p, p53 iso2 (mouse): S312‑p, p53 (rat): S313‑p, p53 (rabbit): S313‑p, p53 (monkey): S315‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial), MCF-7 (breast cell), NCI-H1299 (pulmonary), SW480 (intestinal)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
AurA (human)
|
transfection of inactive enzyme, transfection of constitutively active enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
inhibition, protein degradation
|
|
Effect of modification (process):
apoptosis, inhibited, cell cycle regulation
|
