Curated Information
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PubMed Id: 9687510 
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998) Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J 17, 4426-41 9687510
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S63-p - ATF-1 (human)
Orthologous residues
ATF‑1 (human): S63‑p, ATF‑1 (mouse): S63‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
Ro31-8220 UV inhibit treatment-induced increase
SB203580 UV inhibit treatment-induced increase
PD98059 UV no effect upon treatment-induced increase
EGF increase
Ro31-8220 EGF inhibit treatment-induced increase
PD98059 EGF inhibit treatment-induced increase
SB203580 EGF no effect upon treatment-induced increase
forskolin increase
Ro31-8220 forskolin no effect upon treatment-induced increase
TNF increase
SB203580 TNF inhibit treatment-induced increase
PD98059 TNF no effect upon treatment-induced increase
Ro31-8220 TNF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activity, induced

S133-p - CREB (human)
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), HeLa (cervical), SK-N-MC (neural crest)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE p90RSK (human)
KINASE MSK1 (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
Ro31-8220 UV inhibit treatment-induced increase
SB203580 UV inhibit treatment-induced increase
PD98059 UV no effect upon treatment-induced increase
EGF increase
Ro31-8220 EGF inhibit treatment-induced increase
PD98059 EGF inhibit treatment-induced increase
SB203580 EGF no effect upon treatment-induced increase
forskolin increase
Ro31-8220 forskolin no effect upon treatment-induced increase
TNF increase
SB203580 TNF inhibit treatment-induced increase
PD98059 TNF no effect upon treatment-induced increase
Ro31-8220 TNF inhibit treatment-induced increase

S133-p - CREB (rat)
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  adrenal cancer, pheochromocytoma
 Relevant cell lines - cell types - tissues:  PC-12 (chromaffin)
 Cellular systems studied:  cell lines
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MSK1 (human)
KINASE p90RSK (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
Ro31-8220 UV inhibit treatment-induced increase
SB203580 UV inhibit treatment-induced increase
PD98059 UV no effect upon treatment-induced increase
EGF increase
Ro31-8220 EGF inhibit treatment-induced increase
PD98059 EGF inhibit treatment-induced increase
SB203580 EGF no effect upon treatment-induced increase
forskolin increase
Ro31-8220 forskolin no effect upon treatment-induced increase
TNF increase
SB203580 TNF inhibit treatment-induced increase
PD98059 TNF no effect upon treatment-induced increase
Ro31-8220 TNF inhibit treatment-induced increase
NGF increase
Downstream Regulation
 Effect of modification (function):  activity, induced


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