Curated Information
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Curated Information Page
PubMed Id: 16251902 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Basu U, et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508-11 16251902
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T27-p - AID (mouse) ▲
Orthologous residues
AID (human): T27‑p, AID (mouse): T27‑p, AID (rat): ‑
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKACa (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RPA1 (human) Induces affinity chromatography
 Comments:  promotes deamination of transcribed dsDNA substrates in B cells

S38-p - AID (mouse) ▲
Orthologous residues
AID (human): S38‑p, AID (mouse): S38‑p, AID (rat): S9‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKACa (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RPA1 (human) Induces affinity chromatography
 Comments:  promotes deamination of transcribed dsDNA substrates in B cells

Y184-p - AID (mouse) ▲
Orthologous residues
AID (human): Y184‑p, AID (mouse): Y184‑p, AID (rat): Y155‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse


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