Curated Information
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Curated Information Page
PubMed Id: 16251902 
Basu U, et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508-11 16251902
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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T27-p - AID (mouse)
Orthologous residues
AID (human): T27‑p, AID (mouse): T27‑p, AID (rat):
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RPA1 (human) Induces affinity chromatography
 Comments:  promotes deamination of transcribed dsDNA substrates in B cells

S38-p - AID (mouse)
Orthologous residues
AID (human): S38‑p, AID (mouse): S38‑p, AID (rat): S9‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RPA1 (human) Induces affinity chromatography
 Comments:  promotes deamination of transcribed dsDNA substrates in B cells

Y184-p - AID (mouse)
Orthologous residues
AID (human): Y184‑p, AID (mouse): Y184‑p, AID (rat): Y155‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), B lymphocyte-spleen
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse


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