Curated Information
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PubMed Id: 8622669 
Raingeaud J, et al. (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16, 1247-55 8622669
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S218-p - MKK3 (human)
Orthologous residues
MKK3 (human): S218‑p, MKK3 (mouse): S218‑p, MKK3 (rat): S290‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  transcription, induced

T222-p - MKK3 (human)
Orthologous residues
MKK3 (human): T222‑p, MKK3 (mouse): T222‑p, MKK3 (rat): T294‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  transcription, induced

S207-p - MKK6 (human)
Orthologous residues
MKK6 (human): S207‑p, MKK6 iso2 (human): S151‑p, MKK6 (mouse): S207‑p, MKK6 (rat): S207‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  transcription, induced

T211-p - MKK6 (human)
Orthologous residues
MKK6 (human): T211‑p, MKK6 iso2 (human): T155‑p, MKK6 (mouse): T211‑p, MKK6 (rat): T211‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  transcription, induced

T180-p - P38A (human)
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MKK6 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y182-p - P38A (human)
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MKK6 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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