Curated Information
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Curated Information Page
PubMed Id: 14976311 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Raftopoulou M, et al. (2004) Regulation of cell migration by the C2 domain of the tumor suppressor PTEN. Science 303, 1179-81 14976311
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T383-p - PTEN (human)
Orthologous residues
PTEN (human): T383‑p, PTEN (mouse): T383‑p, PTEN (rat): T383‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast), U138 (glial), U373 MG (glial), U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell motility, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PTEN (human) Induces co-immunoprecipitation, electrophoretic visualization


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