Curated Information
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Curated Information Page
PubMed Id: 15733852 
El-Kady A, Klenova E (2005) Regulation of the transcription factor, CTCF, by phosphorylation with protein kinase CK2. FEBS Lett 579, 1424-34 15733852
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S612-p - CTCF (chicken)
Orthologous residues
CTCF (human): S612‑p, CTCF (mouse): S612‑p, CTCF (rat): S612‑p, CTCF (chicken): S612‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (human) transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  transcription, induced
 Comments:  Phosphorylation mutant S612A inhibited transcriptional repression of transcription (CAT activity than wild-type CTCF.Phosphorylation mutant S612A showed transcriptional repression (CAT activity) not significantly different from wild-type after co-transfection with CK2.S612A also did not significanty alter growth suppression of COS7 cells in comparison with wild-type.


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