Curated Information
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Curated Information Page
PubMed Id: 10531372 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang J, Frost JA, Cobb MH, Ross EM (1999) Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase. J Biol Chem 274, 31641-7 10531372
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S16-p - G-alpha(z) (human)
Orthologous residues
G‑alpha(z) (human): S16‑p, G‑alpha(z) (mouse): S16‑p, G‑alpha(z) (rat): S16‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PAK1 (human)
KINASE PKCA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PAK1 (human) transfection of wild-type enzyme, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase

S27-p - G-alpha(z) (human)
Orthologous residues
G‑alpha(z) (human): S27‑p, G‑alpha(z) (mouse): S27‑p, G‑alpha(z) (rat): S27‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase


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