Curated Information
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Curated Information Page
PubMed Id: 10417351 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Resjö S, et al. (1999) Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A. Biochem J 341 ( Pt 3), 839-45 10417351
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S302-p - PDE3B (rat)
Orthologous residues
PDE3B (human): S318‑p, PDE3B (mouse): S296‑p, PDE3B (rat): S302‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, electrophoretic mobility shift, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  preadipocyte
 Cellular systems studied:  primary cells
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CA (rat) pharmacological inhibitor of upstream enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
okadaic acid increase
calyculin A increase


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