Curated Information

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PubMed Id: 16219768

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Chang NS, et al. (2005) WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. J Biol Chem 280, 43100-8 16219768

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S46-p - p53 (human)

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Orthologous residues

p53 (human): S46‑p, p53 (mouse): L43‑p, p53 iso2 (mouse): L46‑p, p53 (rat): L48‑p, p53 (rabbit): S45‑p, p53 (monkey): S46‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: L929 (fibroblast), U-937 (myeloid)

Cellular systems studied: cell lines

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
UV				increase

Y33-p - WWOX (human)

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Orthologous residues

WWOX (human): Y33‑p, WWOX (mouse): Y33‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: L929 (fibroblast), U-937 (myeloid)

Cellular systems studied: cell lines

Comments: phosphorylation of WWOX occurs during its binding with p53

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
UV				increase

Downstream Regulation

Effect of modification (function): intracellular localization, molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
p53 (human)		Induces	protein stabilization	apoptosis, altered	yeast two-hybrid

Comments: formation of the complex with p53 occurs in the presence of MDM2

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