Curated Information
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Curated Information Page
PubMed Id: 16209943 
Goswami A, et al. (2005) Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell 20, 33-44 16209943
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T155-p - PAR-4 (rat)
Orthologous residues
PAR‑4 (human): T163‑p, PAR‑4 (mouse): T156‑p, PAR‑4 (rat): T155‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), LNCaP (prostate cell), PC3 (prostate cell)
 Cellular systems studied:  cell lines
 Species studied:  human

S249-p - PAR-4 (rat)
Orthologous residues
PAR‑4 (human): N257‑p, PAR‑4 (mouse): N250‑p, PAR‑4 (rat): S249‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), LNCaP (prostate cell), PC3 (prostate cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) phospho-motif antibody
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  apoptosis, inhibited
 Comments:  phosphorylation by Akt prevents apoptosis


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