Curated Information
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Curated Information Page
PubMed Id: 2449432 
White MF, Shoelson SE, Keutmann H, Kahn CR (1988) A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 263, 2969-80 2449432
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1186-p - InsR (rat)
Orthologous residues
InsR (human): Y1185‑p, InsR iso2 (human): Y1173‑p, InsR (mouse): Y1175‑p, InsR (rat): Y1186‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Fao (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE InsR (rat)

Y1190-p - InsR (rat)
Orthologous residues
InsR (human): Y1189‑p, InsR iso2 (human): Y1177‑p, InsR (mouse): Y1179‑p, InsR (rat): Y1190‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Fao (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE InsR (rat)

Y1191-p - InsR (rat)
Orthologous residues
InsR (human): Y1190‑p, InsR iso2 (human): Y1178‑p, InsR (mouse): Y1180‑p, InsR (rat): Y1191‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  Fao (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE InsR (rat)

Y1356-p - InsR (rat)
Orthologous residues
InsR (human): Y1355‑p, InsR iso2 (human): Y1343‑p, InsR (mouse): Y1345‑p, InsR (rat): Y1356‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE InsR (rat)

Y1362-p - InsR (rat)
Orthologous residues
InsR (human): Y1361‑p, InsR iso2 (human): Y1349‑p, InsR (mouse): Y1351‑p, InsR (rat): Y1362‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE InsR (rat)


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