Curated Information
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Curated Information Page
PubMed Id: 7493944 
Hernández-Sánchez C, et al. (1995) The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis. J Biol Chem 270, 29176-81 7493944
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1161-p - IGF1R (human)
Orthologous residues
IGF1R (human): Y1161‑p, IGF1R (mouse): Y1163‑p, IGF1R (rat): Y1162‑p, IGF1R (pig): Y1161‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IGF1R (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Comments:  Signaling through Shc and IRS-1 pathways, IGF-1-stimulated cell growth in culture and tumor formation in nude mice.

Y1165-p - IGF1R (human)
Orthologous residues
IGF1R (human): Y1165‑p, IGF1R (mouse): Y1167‑p, IGF1R (rat): Y1166‑p, IGF1R (pig): Y1165‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IGF1R (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
 Comments:  Signaling through Shc and IRS-1 pathways, IGF-1-stimulated cell growth in culture and tumor formation in nude mice.


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