Curated Information

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Curated Information Page

PubMed Id: 7493944

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Hernández-Sánchez C, et al. (1995) The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis. J Biol Chem 270, 29176-81 7493944

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y1161-p - IGF1R (human)

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Orthologous residues

IGF1R (human): Y1161‑p, IGF1R (mouse): Y1163‑p, IGF1R (rat): Y1162‑p, IGF1R (pig): Y1161‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]

Cellular systems studied: cell lines

Species studied: mouse

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	IGF1R (human)	pharmacological activator of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
IGF-1				increase

Downstream Regulation

Comments: Signaling through Shc and IRS-1 pathways, IGF-1-stimulated cell growth in culture and tumor formation in nude mice.

Y1165-p - IGF1R (human)

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