Curated Information
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Curated Information Page
PubMed Id: 9108484 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Drewes G, et al. (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89, 297-308 9108484
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1679-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1679‑p, MAP2 iso2 (human): S323‑p, MAP2 iso3 (human): S1675‑p, MAP2 iso4 (human): S380‑p, MAP2 (mouse): S1680‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S319‑p, MAP2 (rat): S1682‑p, MAP2 iso2 (rat): S1682‑p, MAP2 iso3 (rat): S319‑p

S1710-p - MAP2 (human)
Orthologous residues
MAP2 (human): S1710‑p, MAP2 iso2 (human): S354‑p, MAP2 iso3 (human): S1706‑p, MAP2 iso4 (human): S442‑p, MAP2 (mouse): S1711‑p, MAP2 iso2 (mouse): , MAP2 iso6 (mouse): S381‑p, MAP2 (rat): S1744‑p, MAP2 iso2 (rat): S1713‑p, MAP2 iso3 (rat): S350‑p

S262-p - Tau iso8 (human)
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK2 (rat)
KINASE MARK1 (rat)

S293-p - Tau iso8 (human)
Orthologous residues
Tau (human): S610‑p, Tau iso2 (human): , Tau iso3 (human): , Tau iso5 (human): , Tau iso6 (human): S235‑p, Tau iso7 (human): S264‑p, Tau iso8 (human): S293‑p, Tau (mouse): S585‑p, Tau iso3 (mouse): S282‑p, Tau iso7 (mouse): S242‑p, Tau (rat): S604‑p, Tau (cow): S300‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK1 (rat)
KINASE MARK2 (rat)

S324-p - Tau iso8 (human)
Orthologous residues
Tau (human): S641‑p, Tau iso2 (human): S235‑p, Tau iso3 (human): S199‑p, Tau iso5 (human): S293‑p, Tau iso6 (human): S266‑p, Tau iso7 (human): S295‑p, Tau iso8 (human): S324‑p, Tau (mouse): S616‑p, Tau iso3 (mouse): S313‑p, Tau iso7 (mouse): S273‑p, Tau (rat): S635‑p, Tau (cow): S331‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK2 (rat)
KINASE MARK1 (rat)

S356-p - Tau iso8 (human)
Orthologous residues
Tau (human): S673‑p, Tau iso2 (human): S267‑p, Tau iso3 (human): S231‑p, Tau iso5 (human): S325‑p, Tau iso6 (human): S298‑p, Tau iso7 (human): S327‑p, Tau iso8 (human): S356‑p, Tau (mouse): S648‑p, Tau iso3 (mouse): S345‑p, Tau iso7 (mouse): S305‑p, Tau (rat): S667‑p, Tau (cow): S363‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphopeptide mapping
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MARK1 (rat)
KINASE MARK2 (rat)

T215-p - MARK1 (rat)
Orthologous residues
MARK1 (human): T215‑p, MARK1 (mouse): T215‑p, MARK1 (rat): T215‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, peptide sequencing
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S219-p - MARK1 (rat)
Orthologous residues
MARK1 (human): S219‑p, MARK1 (mouse): S219‑p, MARK1 (rat): S219‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, peptide sequencing
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

T208-p - MARK2 (rat)
Orthologous residues
MARK2 (human): T208‑p, MARK2 iso4 (human): T208‑p, MARK2 iso10 (human): T175‑p, MARK2 iso13 (human): T175‑p, MARK2 iso14 (human): T175‑p, MARK2 (mouse): T208‑p, MARK2 iso3 (mouse): T208‑p, MARK2 (rat): T208‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, peptide sequencing
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S212-p - MARK2 (rat)
Orthologous residues
MARK2 (human): S212‑p, MARK2 iso4 (human): S212‑p, MARK2 iso10 (human): S179‑p, MARK2 iso13 (human): S179‑p, MARK2 iso14 (human): S179‑p, MARK2 (mouse): S212‑p, MARK2 iso3 (mouse): S212‑p, MARK2 (rat): S212‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, peptide sequencing
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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