Curated Information

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PubMed Id: 16107690

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Kadri Z, et al. (2005) Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol 25, 7412-22 16107690

S310-p - GATA1 (human)

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Orthologous residues

GATA1 (human): S310‑p, GATA1 (mouse): S310‑p, GATA1 (rat): S310‑p, GATA1 (chicken): S216‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: COS (fibroblast), UT-7 (myeloid)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Akt1 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Akt1 (human)	phospho-motif antibody

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
Epo				increase

Downstream Regulation

Effect of modification (process): transcription, altered

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