Curated Information

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Curated Information Page

PubMed Id: 19104148

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Kim KK, et al. (2009) Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119, 213-24 19104148

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y654-p - CTNNB1 (human)

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Orthologous residues

CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'epithelial, lung', lung

Cellular systems studied: primary cells, tissue

Species studied: human, mouse

Downstream Regulation

Effect of modification (function): molecular association, regulation

Effect of modification (process): cytoskeletal reorganization

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
Smad2 (mouse)		Induces	intracellular localization		co-immunoprecipitation
Smad2 (human)		Induces	intracellular localization		co-immunoprecipitation

Comments: nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung

Associated Diseases

Diseases:	Alterations:	Comments:
		idiopathic pulmonary fibrosis

Y654-p - CTNNB1 (mouse)

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