Curated Information
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Curated Information Page
PubMed Id: 19104148 
Kim KK, et al. (2009) Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119, 213-24 19104148
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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Y654-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'epithelial, lung', lung
 Cellular systems studied:  primary cells, tissue
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Smad2 (human) Induces intracellular localization co-immunoprecipitation
Smad2 (mouse) Induces intracellular localization co-immunoprecipitation
 Comments:  nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung
Associated Diseases
Diseases: Alterations: Comments:
idiopathic pulmonary fibrosis

Y654-p - CTNNB1 (mouse)
Orthologous residues
CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'epithelial, lung', lung
 Cellular systems studied:  primary cells, tissue
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Smad2 (mouse) Induces intracellular localization co-immunoprecipitation
Smad2 (human) Induces intracellular localization co-immunoprecipitation
 Comments:  nuclear accumulation in ideopathic pulmonary fibrosis (IPF) in lung
Associated Diseases
Diseases: Alterations: Comments:
idiopathic pulmonary fibrosis


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