Curated Information
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Curated Information Page
PubMed Id: 19251743 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Muñoz MC, et al. (2009) TANK-binding kinase 1 mediates phosphorylation of insulin receptor at serine residue 994: a potential link between inflammation and insulin resistance. J Endocrinol 201, 185-97 19251743
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T308-p - Akt1 (rat) ▲
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats

S9-p - GSK3B (rat) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats

Y1000-p - InsR (rat) ▲
Orthologous residues
InsR (human): Y999‑p, InsR iso2 (human): Y987‑p, InsR (mouse): Y989‑p, InsR (rat): Y1000‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats

S1034-p - InsR (rat) ▲
Orthologous residues
InsR (human): S1033‑p, InsR iso2 (human): S1021‑p, InsR (mouse): S1023‑p, InsR (rat): S1034‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE TBK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TBK1 (rat) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin decrease basal phosphorylation high in obese rats, insulin decreased it slightly
irbesartan insulin augment treatment-induced decrease only in obese rats
TNF increase

Y1186-p - InsR (rat) ▲
Orthologous residues
InsR (human): Y1185‑p, InsR iso2 (human): Y1173‑p, InsR (mouse): Y1175‑p, InsR (rat): Y1186‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats

Y1190-p - InsR (rat) ▲
Orthologous residues
InsR (human): Y1189‑p, InsR iso2 (human): Y1177‑p, InsR (mouse): Y1179‑p, InsR (rat): Y1190‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats

Y1191-p - InsR (rat) ▲
Orthologous residues
InsR (human): Y1190‑p, InsR iso2 (human): Y1178‑p, InsR (mouse): Y1180‑p, InsR (rat): Y1191‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  liver
 Cellular systems studied:  tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase smaller increase in obese rats
irbesartan insulin augment treatment-induced increase in obese rats


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