Curated Information
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Curated Information Page
PubMed Id: 19209902 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zwang NA, et al. (2009) Identification of phosphorylation-dependent binding partners of aquaporin-2 using protein mass spectrometry. J Proteome Res 8, 1540-54 19209902
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S256-p - AQP2 (rat) ▲
Orthologous residues
AQP2 (human): S256‑p, AQP2 (mouse): S256‑p, AQP2 (rat): S256‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  'kidney, inner medulla', MDCK (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  dog, rat
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
GRP78 (rat) Induces co-immunoprecipitation, pull-down assay
HSC70 (rat) Disrupts pull-down assay
HSP70 (rat) Disrupts pull-down assay
PPP1CA (rat) Disrupts co-immunoprecipitation, pull-down assay
RAN (rat) Disrupts pull-down assay
ANXA2 (rat) Disrupts co-immunoprecipitation, pull-down assay
GDI2 (rat) Disrupts pull-down assay

S261-p - AQP2 (rat) ▲
Orthologous residues
AQP2 (human): S261‑p, AQP2 (mouse): S261‑p, AQP2 (rat): S261‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  'kidney, inner medulla'
 Cellular systems studied:  primary cells
 Species studied:  rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ANXA2 (rat) Disrupts pull-down assay
GRP78 (rat) Disrupts pull-down assay
RAN (rat) Disrupts pull-down assay
PPP1CA (rat) Disrupts pull-down assay
HSP70 (rat) Disrupts pull-down assay
HSC70 (rat) Disrupts pull-down assay
GDI2 (rat) Disrupts pull-down assay


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