|
Orthologous residues
|
|
mTOR (human): S2481‑p, mTOR (mouse): S2481‑p, mTOR (rat): S2481‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293 (epithelial), CTLL (T lymphocyte)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, mouse
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
mTOR (human)
|
transfection of wild-type enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
serum
|
|
|
|
increase
|
|
|
wortmannin
|
|
|
|
decrease
|
|
|
rapamycin
|
|
|
|
no change compared to control
|
|
|
calyculin A
|
|
|
|
no change compared to control
|
|
|
histidinol
|
|
|
|
no change compared to control
|
|
|
wortmannin
|
|
|
|
decrease
|
|
|
rapamycin
|
|
|
|
no change compared to control
|
|
|
calyculin A
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
enzymatic activity, induced
|
