Curated Information

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PubMed Id: 18785202

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Zhu H, et al. (2008) 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. Int J Cancer 123, 2741-9 18785202

S15-p - p53 (human)

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Orthologous residues

p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: colorectal cancer, colorectal carcinoma

Relevant cell lines - cell types - tissues: HCT116 (intestinal)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Manipulated Protein	Effect	Notes
	ALOX15 (human)	increase	wild-type ALOX15
	ALOX15 (human)	no effect upon treatment-induced increase	inactive ALOX15
wortmannin		inhibit treatment-induced increase
	DNA-PK (human), ALOX15 (human)	augment treatment-induced increase	AZLOX15 binds to DNA-PK and increases activity and S15 p53 phosphorylation.
siRNA	DNA-PK (human)	inhibit treatment-induced increase

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