Curated Information
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Curated Information Page
PubMed Id: 10358076 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Guo S, et al. (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274, 17184-92 10358076
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T24-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): T24‑p, FOXO1A (mouse): T24‑p, FOXO1A (rat): T24‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human

S256-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): S256‑p, FOXO1A (mouse): S253‑p, FOXO1A (rat): S250‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  transcription, inhibited
 Comments:  Phosphorylation of FKHR at Ser256 is required to disrupt IRS-dependent transactivation by FOXO1A.

S319-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): S319‑p, FOXO1A (mouse): S316‑p, FOXO1A (rat): S313‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human


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