Curated Information
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Curated Information Page
PubMed Id: 10358076 
Guo S, et al. (1999) Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274, 17184-92 10358076
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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T24-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): T24‑p, FOXO1A (mouse): T24‑p, FOXO1A (rat): T24‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human

S256-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): S256‑p, FOXO1A (mouse): S253‑p, FOXO1A (rat): S250‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  activity, inhibited
 Effect of modification (process):  transcription, inhibited
 Comments:  Phosphorylation of FKHR at Ser256 is required to disrupt IRS-dependent transactivation by FOXO1A.

S319-p - FOXO1A (human)
Orthologous residues
FOXO1A (human): S319‑p, FOXO1A (mouse): S316‑p, FOXO1A (rat): S313‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human


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