Curated Information
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Curated Information Page
PubMed Id: 16083423 
Vitari AC, Deak M, Morrice NA, Alessi DR (2005) The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J 391, 17-24 16083423
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T185-p - OSR1 (human)
Orthologous residues
OSR1 (human): T185‑p, OSR1 (mouse): T185‑p, OSR1 (rat): T185‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE WNK1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Comments:  mutation of site prevented activation of OSR1 in vitro.

S325-p - OSR1 (human)
Orthologous residues
OSR1 (human): S325‑p, OSR1 (mouse): S325‑p, OSR1 (rat): S325‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE WNK1 (human)

T231-p - STLK3 (human)
Orthologous residues
STLK3 (human): T231‑p, STLK3 (mouse): T243‑p, STLK3 (rat): T240‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE WNK1 (human)

S371-p - STLK3 (human)
Orthologous residues
STLK3 (human): S371‑p, STLK3 (mouse): S383‑p, STLK3 (rat): S380‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE WNK1 (human)


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