Curated Information
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Curated Information Page
PubMed Id: 19004816 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Inglis KJ, et al. (2009) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem 284, 2598-602 19004816
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S129-p - SNCA (human)
Orthologous residues
SNCA (human): S129‑p, SNCA (mouse): S129‑p, SNCA (rat): S129‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), neuron-'brain, cerebral cortex'
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK2 (human)
KINASE PLK3 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK2 (mouse) pharmacological inhibitor of upstream enzyme, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme, siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DMAT decrease
BI2536 decrease
APMU decrease


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