Curated Information
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Curated Information Page
PubMed Id: 15998322 
Johnson JL, et al. (2005) Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic 6, 667-81 15998322
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S8-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S8‑p, SYTL1 iso2 (human): S8‑p, SYTL1 (mouse): S8‑p, SYTL1 (rat): S8‑p

S69-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S69‑p, SYTL1 iso2 (human): S69‑p, SYTL1 (mouse): S69‑p, SYTL1 (rat): S69‑p

S111-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S111‑p, SYTL1 iso2 (human): S111‑p, SYTL1 (mouse): S111‑p, SYTL1 (rat): S111‑p

T140-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): T140‑p, SYTL1 iso2 (human): T140‑p, SYTL1 (mouse): S141‑p, SYTL1 (rat): S140‑p

S241-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S241‑p, SYTL1 iso2 (human): S229‑p, SYTL1 (mouse): S245‑p, SYTL1 (rat): S239‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAB27A (human) Not reported

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