Curated Information
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Curated Information Page
PubMed Id: 15998322 
Johnson JL, et al. (2005) Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic 6, 667-81 15998322
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S8-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S8‑p, SYTL1 (mouse): S8‑p, SYTL1 (rat): S8‑p

S69-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S69‑p, SYTL1 (mouse): S69‑p, SYTL1 (rat): S69‑p

S111-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S111‑p, SYTL1 (mouse): S111‑p, SYTL1 (rat): S111‑p

T140-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): T140‑p, SYTL1 (mouse): S141‑p

S241-p - SYTL1 (human)
Orthologous residues
SYTL1 (human): S241‑p, SYTL1 (mouse): S245‑p, SYTL1 (rat): S239‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LY294002 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAB27A (human) Not reported


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