Curated Information
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Curated Information Page
PubMed Id: 16009340 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Freeley M, Volkov Y, Kelleher D, Long A (2005) Stimulus-induced phosphorylation of PKC theta at the C-terminal hydrophobic-motif in human T lymphocytes. Biochem Biophys Res Commun 334, 619-30 16009340
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T538-p - PKCT (human)
Orthologous residues
PKCT (human): T538‑p, PKCT (mouse): T538‑p, PKCT (rat): T538‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester no change compared to control
anti-CD3/CD28 no change compared to control

S676-p - PKCT (human)
Orthologous residues
PKCT (human): S676‑p, PKCT (mouse): S676‑p, PKCT (rat): S676‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
anti-CD3/CD28 no change compared to control

S695-p - PKCT (human)
Orthologous residues
PKCT (human): S695‑p, PKCT (mouse): S695‑p, PKCT (rat): S695‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
anti-CD3/CD28 increase
rottlerin anti-CD3/CD28 no effect upon treatment-induced increase
staurosporine anti-CD3/CD28 inhibit treatment-induced increase
Go 6976 anti-CD3/CD28 inhibit treatment-induced increase
rapamycin anti-CD3/CD28 no effect upon treatment-induced increase


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