Curated Information

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Curated Information Page

PubMed Id: 9528769

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Joel PB, et al. (1998) pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol 18, 1978-84 9528769

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S118-p - ER-alpha (human)

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Orthologous residues

ER‑alpha (human): S118‑p, ER‑alpha (mouse): S122‑p, ER‑alpha (rat): S123‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ERK2 (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
EGF				increase

S167-p - ER-alpha (human)

▲

Orthologous residues

ER‑alpha (human): S167‑p, ER‑alpha (mouse): S171‑p, ER‑alpha (rat): S172‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site

Relevant cell lines - cell types - tissues: BHK-21 (fibroblast), COS (fibroblast), MCF-7 (breast cell)

Cellular systems studied: cell lines

Species studied: hamster, human, monkey

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	p90RSK (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	p90RSK (human)	activation of upstream enzyme, mutation in upstream enzyme recognition motif, co-immunoprecipitation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
EGF				increase

Downstream Regulation

Effect of modification (process): transcription, altered

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