Curated Information
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Curated Information Page
PubMed Id: 15890648 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sigoillot FD, et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J Biol Chem 280, 25611-20 15890648
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T456-p - CAD (human) ▲
Orthologous residues
CAD (human): T456‑p, CAD (mouse): T456‑p, CAD iso2 (mouse): ‑, CAD (rat): T456‑p, CAD (hamster): T456‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), BHK-21 (fibroblast), BHK165-23 (fibroblast), CRL2081 (pulmonary), MCF-10A (breast cell), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) activation of upstream enzyme
KINASE ERK1 (human) activation of upstream enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization


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