Curated Information
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PubMed Id: 14976552 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lizcano JM, et al. (2004) LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23, 833-43 14976552
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T205-p - BRSK1 iso2 (human) ▲
Orthologous residues
BRSK1 (human): T189‑p, BRSK1 iso2 (human): T205‑p, BRSK1 (mouse): T189‑p, BRSK1 (rat): T189‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)

T174-p - BRSK2 (human) ▲
Orthologous residues
BRSK2 (human): T174‑p, BRSK2 iso4 (human): T174‑p, BRSK2 (mouse): T175‑p, BRSK2 (rat): T175‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)

T215-p - MARK1 (human) ▲
Orthologous residues
MARK1 (human): T215‑p, MARK1 (mouse): T215‑p, MARK1 (rat): T215‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T208-p - MARK2 (human) ▲
Orthologous residues
MARK2 (human): T208‑p, MARK2 iso3 (human): T175‑p, MARK2 iso4 (human): T208‑p, MARK2 iso10 (human): T175‑p, MARK2 iso13 (human): T175‑p, MARK2 (mouse): T208‑p, MARK2 iso3 (mouse): T208‑p, MARK2 (rat): T208‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T211-p - MARK3 (human) ▲
Orthologous residues
MARK3 (human): T211‑p, MARK3 iso3 (human): T211‑p, MARK3 iso6 (human): T211‑p, MARK3 (mouse): T211‑p, MARK3 (rat): T211‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

S215-p - MARK3 (human) ▲
Orthologous residues
MARK3 (human): S215‑p, MARK3 iso3 (human): S215‑p, MARK3 iso6 (human): S215‑p, MARK3 (mouse): S215‑p, MARK3 (rat): S215‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)

T214-p - MARK4 (human) ▲
Orthologous residues
MARK4 (human): T214‑p, MARK4 (mouse): T214‑p, MARK4 (rat): T214‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T167-p - MELK (human) ▲
Orthologous residues
MELK (human): T167‑p, MELK (mouse): T167‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)

T211-p - NuaK1 (human) ▲
Orthologous residues
NuaK1 (human): T211‑p, NuaK1 (mouse): T212‑p, NuaK1 (rat): T212‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)

T208-p - NuaK2 (human) ▲
Orthologous residues
NuaK2 (human): T208‑p, NuaK2 (mouse): T220‑p, NuaK2 (rat): T212‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T175-p - QIK (human) ▲
Orthologous residues
QIK (human): T175‑p, QIK (mouse): T175‑p, QIK (rat): T175‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T271-p - QSK iso5 (human) ▲
Orthologous residues
QSK (human): T163‑p, QSK iso2 (human): ‑, QSK iso4 (human): T163‑p, QSK iso5 (human): T271‑p, QSK (mouse): T163‑p, QSK (rat): T136‑p, QSK iso2 (rat): ‑
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody

T182-p - SIK (human) ▲
Orthologous residues
SIK (human): T182‑p, SIK (mouse): T182‑p, SIK (rat): T182‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, peptide sequencing
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [LKB1 (human)], MEF (fibroblast) [LKB1 (human)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE LKB1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) transfection of wild-type enzyme, transfection of inactive enzyme, phospho-antibody


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