Curated Information
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Curated Information Page
PubMed Id: 11319165 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Johnson AL, Bridgham JT, Swenson JA (2001) Activation of the Akt/protein kinase B signaling pathway is associated with granulosa cell survival. Biol Reprod 64, 1566-74 11319165
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S474-p - Akt2 (human)
Orthologous residues
Akt2 (human): S474‑p, Akt2 (mouse): S474‑p, Akt2 (rat): S474‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  preovulatory follicle granulosa
 Cellular systems studied:  primary cultured cells
 Species studied:  chicken
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
LY294002 IGF-1 inhibit treatment-induced increase
U0126 IGF-1 no effect upon treatment-induced increase
PD98059 IGF-1 no effect upon treatment-induced increase
TGF-alpha increase
LY294002 TGF-alpha inhibit treatment-induced increase
U0126 TGF-alpha no effect upon treatment-induced increase
PD98059 TGF-alpha no effect upon treatment-induced increase
FGF1 no change compared to control
PDGF no change compared to control
LH no change compared to control
cAMP analog no change compared to control


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